Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Xia & He Publishing PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect