Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification